Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial
Plewes K., Kingston HWF., Ghose A., Wattanakul T., Hassan MMU., Haider MS., Dutta PK., Islam MA., Alam S., Jahangir SM., Zahed ASM., Sattar MA., Chowdhury MAH., Herdman MT., Leopold SJ., Ishioka H., Piera KA., Charunwatthana P., Silamut K., Yeo TW., Lee SJ., Mukaka M., Maude RJ., Turner GDH., Faiz MA., Tarning J., Oates JA., Anstey NM., White NJ., Day NPJ., Hossain MA., Roberts II LJ., Dondorp AM.
This randomized, controlled trial shows that acetaminophen reduces kidney dysfunction and risk of developing acute kidney injury, particularly in severe malaria patients who present with high plasma hemoglobin, supporting the hypothesis that acetaminophen inhibits cell-free hemoglobin-mediated renal tubular oxidative damage.