Accuracy of Different Bioinformatics Methods in Detecting Antibiotic Resistance and Virulence Factors from Staphylococcus aureus Whole-Genome Sequences
Mason A., Foster D., Bradley P., Golubchik T., Doumith M., Gordon NC., Pichon B., Iqbal Z., Staves P., Crook D., Walker AS., Kearns A., Peto T.
In principle, whole-genome sequencing (WGS) can predict phenotypic resistance directly from a genotype, replacing laboratory-based tests. However, the contribution of different bioinformatics methods to genotype-phenotype discrepancies has not been systematically explored to date.