Effect of antiretroviral therapy on plasma concentrations of chloroquine and desethyl-chloroquine.
Ippolito MM., Jacobson JM., Lederman MM., Winterberg M., Tarning J., Shapiro TA., Flexner C.
The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants on protease inhibitor-based ART (n=9), efavirenz-based ART (n=15), other ART (n=8), and those not on ART (n=31). Efavirenz appeared to inhibit chloroquine desethylation.