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Fitness costs are key determinants of whether drug resistance alleles establish and how fast they spread within populations. More than 125 different kelch13 alleles, each containing a different amino acid substitution, have arisen in Southeast Asian malaria parasite ( Plasmodium falciparum ) populations under artemisinin selection over the past 15 years in a dramatic example of a soft selective event.

Original publication

DOI

10.1128/aac.00605-18

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

09/2018

Volume

62