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<jats:title>ABSTRACT</jats:title> <jats:p> <jats:italic>Streptococcus pneumoniae</jats:italic> (the pneumococcus) produces 1 of 91 capsular polysaccharides (CPS) that define the serotype. The <jats:italic>cps</jats:italic> loci of 88 pneumococcal serotypes whose CPS is synthesized by the Wzy-dependent pathway were compared with each other and with additional streptococcal polysaccharide biosynthetic loci and were clustered according to the proportion of shared homology groups (HGs), weighted for the sequence similarities between the genes encoding the shared HGs. The <jats:italic>cps</jats:italic> loci of the 88 pneumococcal serotypes were distributed into eight major clusters and 21 subclusters. All serotypes within the same serogroup fell into the same major cluster, but in six cases, serotypes within the same serogroup were in different subclusters and, conversely, nine subclusters included completely different serotypes. The closely related <jats:italic>cps</jats:italic> loci within a subcluster were compared to the known CPS structures to relate gene content to structure. The <jats:italic>Streptococcus oralis</jats:italic> and <jats:italic>Streptococcus mitis</jats:italic> polysaccharide biosynthetic loci clustered within the pneumococcal <jats:italic>cps</jats:italic> loci and were in a subcluster that also included the <jats:italic>cps</jats:italic> locus of pneumococcal serotype 21, whereas the <jats:italic>Streptococcus agalactiae cps</jats:italic> loci formed a single cluster that was not closely related to any of the pneumococcal <jats:italic>cps</jats:italic> clusters.</jats:p>

Original publication




Journal article


Journal of Bacteriology


American Society for Microbiology

Publication Date





7841 - 7855