Antimalarial transmission-blocking vaccines
Sinden RE., Biswas S., Blagborough AM.
© Springer International Publishing Switzerland 2017. It can be argued correctly that any vaccine that reduces the reproductive potential of a pathogen is a transmission-blocking vaccine; in the context of malaria, a cover-all term ‘vaccines that interrupt malaria transmission’ (VIMT) has recently been invoked to describe such products. Vaccines that impact the transmission of the malaria parasite from the vertebrate host to the mosquito vector-previously termed transmission-blocking vaccines (TBV)-have consequently been renamed ‘sexual, sporogonic and mosquito stage vaccines (SSM-VIMT)', to distinguish them from pre-erythrocytic vaccines targeting the sporozoite as it travels from the mosquito to the hepatocyte. In this chapter, we confine our discussion to TBV as classically described.