The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies
Gibani MM., Voysey M., Jin C., Jones C., Thomaides-Brears H., Jones E., Baker P., Morgan M., Simmons A., Gordon MA., Cerundolo V., Pitzer VE., Angus B., Levine MM., Darton TC., Pollard AJ.
Six Salmonella Typhi or Paratyphi human challenge studies were conducted, and daily stool cultures performed. Vi-containing vaccines reduced bacterial shedding, Ty21a or an experimental vaccine did not. Higher Vi immunoglobulin G titers were associated with reduced shedding.