Direct Ex Vivo Measurement of CD8+T-Lymphocyte Responses to Human Parvovirus B19
Tolfvenstam T., Oxenius A., Price DA., Shacklett BL., Spiegel HML., Hedman K., Norbeck O., Levi M., Olsen K., Kantzanou M., Nixon DF., Broliden K., Klenerman P.
ABSTRACTParvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.