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An enzyme-linked immunosorbent assay (ELISA) was developed to measure specific IgG antibody levels to pneumococcal polysaccharide antigens in 300 children attending various hospital departments. By expressing the results as a specific binding index (SBI) of given high and low controls, good reproducibility was obtained. Serum levels of the antibodies were found to fall rapidly during the 1st year of life, plateau during the 2nd and then rise steadily, reaching adult levels by the 7th year.

Type

Journal article

Journal

J Immunol Methods

Publication Date

23/11/1987

Volume

104

Pages

143 - 148

Keywords

Antibodies, Bacterial, Antigens, Bacterial, Bacterial Vaccines, Child, Dose-Response Relationship, Immunologic, Enzyme-Linked Immunosorbent Assay, Humans, Patients, Polysaccharides, Bacterial, Streptococcus pneumoniae