Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine
Walimbwa SI., Lamorde M., Waitt C., Kaboggoza J., Else L., Byakika-Kibwika P., Amara A., Gini J., Winterberg M., Chiong J., Tarning J., Khoo SH.
Across sub-Saharan Africa, patients with HIV on antiretrovirals often get malaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether-lumefantrine or artesunate-amodiaquine given with 50 mg once daily dolutegravir (DTG) to investigate the drug-drug interaction between artemether-lumefantrine or artesunate-amodiaquine and dolutegravir.