Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

Tye-Din JA., Stewart JA., Dromey JA., Beissbarth T., van Heel DA., Tatham A., Henderson K., Mannering SI., Gianfrani C., Jewell DP., Hill AVS., McCluskey J., Rossjohn J., Anderson RP.

Three highly immunogenic peptides from gluten are primarily responsible for celiac disease, suggesting a rational immunotherapeutic approach that could replace the need for strict, lifelong dietary gluten avoidance.

DOI

10.1126/scitranslmed.3001012

Type

Journal article

Journal

Science Translational Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

21/07/2010

Volume

2

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