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An effective immune response requires the rapid and accurate mobilisation of millions of effector cells in an antigen driven fashion. These effector cells must be kept alive long enough to fulfil their function but the majority must then be eliminated, a process known as activation-induced cell death. Recent advances in the field of lymphocyte biology have shed light onto how this balance is maintained and onto the consequences for disease if the homeostatic mechanisms become disturbed.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

06/2000

Volume

12

Pages

316 - 322

Keywords

Antigens, CD, Cell Death, Models, Immunological, Receptors, TNF-Related Apoptosis-Inducing Ligand, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type I, Signal Transduction, T-Lymphocytes, fas Receptor