Use of likelihood ratios improves clinical interpretation of IgG and IgA anti-DGP antibody testing for celiac disease in adults and children.
Vermeersch P., Richter T., Hauer AC., Stern M., Uhlig HH., Zimmer K-P., Laass MW., Hoffman I., Hiele M., Mothes T., Bossuyt X.
OBJECTIVE: To evaluate whether taking into account anti-deamidated gliadin peptide (DGP) antibody concentrations improves clinical interpretation. DESIGN AND METHODS: We calculated likelihood ratios (LR) using data from two previously published studies for assays from EUROIMMUN and INOVA. RESULTS: LRs markedly increased with increasing IgG anti-DGP concentrations. LRs also increased with increasing IgA anti-DGP concentrations, although they were lower than for IgG anti-DGP. CONCLUSIONS: Use of LRs for different test result intervals improves clinical interpretation.