Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections
Meister I., Assawasuwannakit P., Vanobberghen F., Penny MA., Odermatt P., Sayasone S., Huwyler J., Tarning J., Keiser J.
Opisthorchiasis, caused by the foodborne trematode Opisthorchis viverrini , affects more than 8 million people in Southeast Asia. In the framework of a phase 2b clinical trial conducted in Lao People’s Democratic Republic, pharmacokinetic samples were obtained from 125 adult and adolescent O. viverrini -infected patients treated with 400 mg tribendimidine following the design of a sparse sampling scheme at 20 min and 2, 7.75, 8, and 30 h after treatment using dried blood spot sampling.