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BackgroundPopulation differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we extend this dataset to include additional variants, survey sites with low levels of differentiation, and evaluate the extent to which highly differentiated sites are likely to result from selective or other processes.ResultsWe demonstrate that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high population differentiation are enriched for positive selection events and that one half may be the result of classic selective sweeps. Among these, we rediscover known examples, where we actually identify the established functional SNP, and discover novel examples including the genes ABCA12, CALD1 and ZNF804, which we speculate may be linked to adaptations in skin, calcium metabolism and defense, respectively.ConclusionsWe identify known and many novel candidate regions for geographically restricted positive selection, and suggest several directions for further research.

Original publication

DOI

10.1186/gb-2014-15-6-r88

Type

Journal article

Journal

Genome biology

Publication Date

30/06/2014

Volume

15

Keywords

1000 Genomes Project Consortium, Humans, Sequence Analysis, DNA, Gene Frequency, Genetic Drift, Polymorphism, Single Nucleotide, Genome, Human, INDEL Mutation, Selection, Genetic