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Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay.

Original publication

DOI

10.1016/j.jhin.2019.04.004

Type

Journal article

Journal

The Journal of hospital infection

Publication Date

10/2019

Volume

103

Pages

151 - 155

Addresses

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao Democratic People's Republic.

Keywords

Humans, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, beta-Lactamases, Longitudinal Studies, Carrier State, Drug Resistance, Bacterial, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Thailand, Female, Male