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Search results (129)

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Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures

Lu J. et al, (2026), Signal Transduction and Targeted Therapy, 11

Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response.

Marques A-SMC. et al, (2026), Nature communications

Advances in BRET probes for intracellular target engagement studies

Capener JL. et al, (2026), Nature Chemical Biology, 22, 691 - 701

Abstract 5794: Leveraging E2 ligases for induced proximity and modulation of novel cancer-relevant targets and neosubstrates

Chen X. et al, (2026), Cancer Research, 86, 5794 - 5794

Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITA

Humphrey T. et al, (2026)

A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis

Nguyen T-A. et al, (2025), Science, 390, 1143 - 1150

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells

Rothweiler EM. et al, (2025), Nature Communications, 16

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow TCY. et al, (2025)

Pharmacological targeting of BMAL1 modulates circadian and immune pathways

Pu H. et al, (2025), Nature Chemical Biology, 21, 736 - 745

Drug repurposing in amyotrophic lateral sclerosis (ALS)

Carroll E. et al, (2025), Expert Opinion on Drug Discovery, 20, 447 - 464

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence

Lu J. et al, (2025)

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Marques A-SMC. et al, (2025)

Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine de novo synthesis

Lin J-MG. et al, (2025)

Phenomics‐Based Discovery of Novel Orthosteric Choline Kinase Inhibitors

Bauer LG. et al, (2025), Angewandte Chemie International Edition, 64

A Live Cell BRET Probe to Quantify PRMT5-MTA Uncompetitive Target Engagement

Rothweiler E. et al, (2025)

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