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Search results (116)

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dvances in BRET probes for intracellular target engagement studies

Capener JL. et al, (2026), Nature Chemical Biology

non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis

Nguyen T-A. et al, (2025), Science, 390, 1143 - 1150

BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells

Rothweiler EM. et al, (2025), Nature Communications, 16

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow TCY. et al, (2025)

Pharmacological targeting of BMAL1 modulates circadian and immune pathways

Pu H. et al, (2025), Nature Chemical Biology, 21, 736 - 745

Drug repurposing in amyotrophic lateral sclerosis (ALS)

Carroll E. et al, (2025), Expert Opinion on Drug Discovery, 20, 447 - 464

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence

Lu J. et al, (2025)

Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors.

Bauer LG. et al, (2025), Angewandte Chemie (International ed. in English), 64

Toward target 2035: EUbOPEN - a public–private partnership to enable & unlock biology in the open

Tredup C. et al, (2025), RSC Medicinal Chemistry, 16, 457 - 464

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

Fejes I. et al, (2024), Journal of medicinal chemistry, 67, 21208 - 21222

KLF5 Is a Key Regulator of IMiD-Induced Neutropenia

Simoglou Karali C. et al, (2024), Blood, 144, 2527 - 2527

Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300

Chen X. et al, (2024), JACS Au, 4, 3094 - 3103

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

Lee AA. et al, (2024)

dvancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

Digles D. et al, (2024), Frontiers in Pharmacology, 15

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist

Balıkçı E. et al, (2024), Journal of Medicinal Chemistry, 67, 7245 - 7259

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