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Search results (136)

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Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action

Chen Z. et al, (2026), Immunity & Inflammation, 2

Fragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction.

Lin C. et al, (2025), Angewandte Chemie (International ed. in English), 64

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.

Chen Z. et al, (2025), Nature communications, 16

Toward target 2035: EUbOPEN - a public–private partnership to enable & unlock biology in the open

Tredup C. et al, (2025), RSC Medicinal Chemistry, 16, 457 - 464

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

Fejes I. et al, (2024), Journal of medicinal chemistry, 67, 21208 - 21222

Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors.

Qin Y. et al, (2024), Journal of medicinal chemistry, 67, 18828 - 18864

BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

Pinkas DM. et al, (2024), Structure, 32, 1586 - 1593.e4

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.

Němec V. et al, (2024), Journal of medicinal chemistry, 67, 12632 - 12659

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

Bashore FM. et al, (2024), ACS medicinal chemistry letters, 15, 1325 - 1333

BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1

Pinkas DM. et al, (2024)

BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome

Miller KA. et al, (2024), Journal of Medical Genetics, 61, 490 - 501

Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays

van Veggel L. et al, (2024), ACS Chemical Neuroscience, 15, 1424 - 1431

Discovery of Conformationally Constrained ALK2 Inhibitors.

González-Álvarez H. et al, (2024), Journal of medicinal chemistry, 67, 4707 - 4725

Correction: CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB. et al, (2024), Nature immunology, 25, 371 - 372

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo.

Brown EJ. et al, (2024), Scientific reports, 14

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