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Search results (28)

« Back to Publications

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods

Rayner E. et al, (2019), The CRISPR Journal, 2, 406 - 416

KEAP1-NRF2 Pathway as a Modulator of Response to Radiation in Rectal Cancer

O'Cathail SM. et al, (2018), International Journal of Radiation Oncology*Biology*Physics, 102, e191 - e192

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Baker A-M. et al, (2017), Nature Communications, 8

Bone morphogenetic protein and Notch signalling crosstalk in poor‐prognosis, mesenchymal‐subtype colorectal cancer

Irshad S. et al, (2017), The Journal of Pathology, 242, 178 - 192

WHOLE GENOME CRISPR KNOCKOUT SCREEN AND MURINE ENDOSCOPY IDENTIFIES FOXF1 AS A KEY SUPPRESSOR OF COLORECTAL CANCER METASTASIS THAT ACTS THROUGH MTORC SIGNALLING

Lee L. et al, (2017), GUT, 66, A33 - A33

Five endometrial cancer risk loci identified through genome-wide association analysis

Cheng THT. et al, (2016), Nature Genetics, 48, 667 - 674

berrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Davis H. et al, (2015), Nature Medicine, 21, 62 - 70

Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

Lewis A. et al, (2014), Cell Reports, 8, 983 - 990

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Davis H. et al, (2014), Gut, 63, 792 - 799

basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

Leedham SJ. et al, (2013), Gut, 62, 83 - 93

The Utility of Mouse Models in Post-GWAS Research

Lewis A. and Tomlinson I., (2012), Science, 338, 1301 - 1302

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Jaeger E. et al, (2012), Nature Genetics, 44, 699 - 703

The C‐terminus of Apc does not influence intestinal adenoma development or progression

Lewis A. et al, (2012), The Journal of Pathology, 226, 73 - 83

Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

Tomlinson IPM. et al, (2011), PLoS Genetics, 7, e1002105 - e1002105

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

Davis H. et al, (2011), The Journal of Pathology, 224, 180 - 189

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