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Discovery of Conformationally Constrained ALK2 Inhibitors.

Journal article

González-Álvarez H. et al, (2024), Journal of medicinal chemistry

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2

Journal article

Bashore FM. et al, (2024), ACS Medicinal Chemistry Letters

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

Journal article

Adamson RJ. et al, (2023), Free Radical Biology and Medicine

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

Journal article

Ong HW. et al, (2023), ACS Chem Neurosci

Target 2035 – an update on private sector contributions

Journal article

Ackloo S. et al, (2023), RSC Medicinal Chemistry, 14, 1002 - 1011

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Journal article

Chen Z. et al, (2022), Cell Death & Differentiation, 29, 1955 - 1969

Ubiquitin ligases: guardians of mammalian development

Journal article

Cruz Walma DA. et al, (2022), Nature Reviews Molecular Cell Biology

Target 2035-update on the quest for a probe for every protein

Journal article

Mueller S. et al, (2021), RSC MEDICINAL CHEMISTRY

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.

Journal article

Röhm S. et al, (2021), Journal of medicinal chemistry, 64, 13451 - 13474

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

Journal article

Ventura F. et al, (2021), Biomedicines, 9, 213 - 213

ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

Journal article

Williams E. et al, (2021), Biomedicines, 9, 129 - 129

DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity

Journal article

Schröder M. et al, (2020), Journal of Medicinal Chemistry, 63, 10224 - 10234

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.

Journal article

Ensan D. et al, (2020), Journal of medicinal chemistry, 63, 4978 - 4996

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