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Publications

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods.

Rayner E. et al, (2019), The CRISPR journal, 2, 406 - 416

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Baker A-M. et al, (2017), Nature Communications, 8

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer

Irshad S. et al, (2017), The Journal of Pathology, 242, 178 - 192

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer

Irshad S. et al, (2017), The Journal of Pathology, 242, 178 - 192

Five endometrial cancer risk loci identified through genome-wide association analysis

Cheng THT. et al, (2016), Nature Genetics, 48, 667 - 674

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Davis H. et al, (2015), Nature Medicine, 21, 62 - 70

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

Lewis A. et al, (2014), Cell Reports, 8, 983 - 990

Investigation of the atypicalFBXW7mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Davis H. et al, (2014), Gut, 63, 792 - 799

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

Leedham SJ. et al, (2013), Gut, 62, 83 - 93

The Utility of Mouse Models in Post-GWAS Research

Lewis A. and Tomlinson I., (2012), Science, 338, 1301 - 1302

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Jaeger E. et al, (2012), Nature Genetics, 44, 699 - 703

The C-terminus of Apc does not influence intestinal adenoma development or progression

Lewis A. et al, (2012), The Journal of Pathology, 226, 73 - 83

Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

Tomlinson IPM. et al, (2011), PLoS Genetics, 7, e1002105 - e1002105

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

Davis H. et al, (2011), The Journal of Pathology, 224, 180 - 189

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

Babaei-Jadidi R. et al, (2011), Journal of Experimental Medicine, 208, 295 - 312

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

Lewis A. et al, (2010), Gut, 59, 1680 - 1686

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

Pollard P. et al, (2009), Gastroenterology, 136, 2204 - 2213.e13

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing.

Redrup L. et al, (2009), Development, 136, 525 - 530

A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA.

Green K. et al, (2007), Mamm Genome, 18, 32 - 42

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.

Lewis A. et al, (2006), Development, 133, 4203 - 4210

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