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Publications

Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma.

Carroll TM. et al, (2023), Cancer cell, 41, 1222 - 1241.e7

Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression.

Ramirez-Valdez RA. et al, (2023), Cell reports, 42

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.

Solvay M. et al, (2023), Journal for immunotherapy of cancer, 11

Tumour immune rejection triggered by activation of α2-adrenergic receptors.

Zhu J. et al, (2023), Nature

Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression.

Finisguerra V. et al, (2023), Journal for immunotherapy of cancer, 11

Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer.

Naulaerts S. et al, (2023), Sci Transl Med, 15

Editorial: Heme proteins: key players in the regulation of immune responses.

Volpi C. et al, (2023), Front Immunol, 14

Combining personalized neoantigen vaccination with chemotherapy and anti-PD-1 to treat NSCLC.

Leung CSK. and Van den Eynde BJ., (2022), Cancer Cell

New Insights into the Mechanisms of Proteasome-Mediated Peptide Splicing Learned from Comparing Splicing Efficiency by Different Proteasome Subtypes.

Ferrari V. et al, (2022), Journal of immunology (Baltimore, Md. : 1950)

T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor antibody penetration and improves PD-L1 blocking at the tumor site

Petit P-F. et al, (2022), Cancer Immunology Research

Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.

Lahman MC. et al, (2022), Science translational medicine, 14

Navigating Critical Challenges Associated with Immunopeptidomics-Based Detection of Proteasomal Spliced Peptide Candidates

Lichti CF. et al, (2022), Cancer Immunology Research

Functional Differences between Proteasome Subtypes.

Abi Habib J. et al, (2022), Cells, 11

Systemic tryptophan homeostasis.

Klaessens S. et al, (2022), Frontiers in molecular biosciences, 9

Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase.

Kozlova A. et al, (2021), European journal of medicinal chemistry, 227

Heterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy.

McAuliffe J. et al, (2021), J Immunother Cancer, 9

Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase.

Kozlova A. et al, (2021), Journal of medicinal chemistry, 64, 10967 - 10980

Arid5a: A Missing Link between EMT and Tumoral Immune Resistance

Van den Eynde BJ., (2021), Cancer Immunology Research

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Klaessens S. et al, (2021), Proceedings of the National Academy of Sciences, 118, e2022447118 - e2022447118

IDO1 and TDO inhibitory evaluation of analogues of the marine pyrroloiminoquinone alkaloids: Wakayin and Tsitsikammamines.

Levy T. et al, (2021), Bioorganic & medicinal chemistry letters, 40

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