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Publications

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Barrett JR. et al, (2021), Nature Medicine, 27, 279 - 288

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Ewer KJ. et al, (2021), Nature Medicine, 27, 270 - 278

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Voysey M. et al, (2021), The Lancet, 397, 99 - 111

Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis.

Mandriota SJ. et al, (2020), International journal of molecular sciences, 21

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993

Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma.

Tamura N. et al, (2020), Cancer research

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

Yeow ZY. et al, (2020), Nature, 585, 447 - 452

ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

Wells D. et al, (2020), eLife, 9

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Folegatti PM. et al, (2020), The Lancet, 396, 467 - 478

The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates

Hinch AG. et al, (2020), Molecular Cell, 79, 689 - 701.e10

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.

Nelson L. et al, (2020), Nature communications, 11

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods.

Rayner E. et al, (2019), The CRISPR journal

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

Wells D. et al, (2019)

The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23): Revised characterisation of cytogenetic features.

Ragusa D. et al, (2019), Cancer reports (Hoboken, N.J.), 2

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization.

Rudzka DA. et al, (2019), J Cell Sci, 132

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.

Gdula MR. et al, (2019), Nat Commun, 10

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α.

Simões-Sousa S. et al, (2018), Cell Rep, 25, 749 - 760.e6

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

Ghezraoui H. et al, (2018), Nature, 560, 122 - 127

PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions

Wilson RHC. et al, (2017), DNA Repair, 50, 22 - 35

Repo-Man/PP1 regulates heterochromatin formation in interphase.

de Castro IJ. et al, (2017), Nat Commun, 8

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