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The energetics and ion coupling of cholesterol transport through Patched1

Journal article

Ansell TB. et al, (2023), Science Advances, 9

Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family.

Journal article

Coupland CE. et al, (2023), Curr Opin Struct Biol, 80

The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.

Journal article

Siebold C. and Rohatgi R., (2023), Annu Rev Biochem

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Journal article

Coupland CE. et al, (2021), Molecular cell, 81, 5025 - 5038.e10

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Journal article

Griffiths SC. et al, (2021), Nature Communications, 12

Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Journal article

Ansell TB. et al, (2021), Journal of Chemical Theory and Computation, 17, 6548 - 6558

Structure and Mechanism of Hedgehog Acyl Transferase

Journal article

Coupland CE. et al, (2021)

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**

Journal article

Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.

Journal article

Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Journal article

Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31

Cholesterol access in cellular membranes controls Hedgehog signaling.

Journal article

Radhakrishnan A. et al, (2020), Nature chemical biology, 16, 1303 - 1313

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

Journal article

McGough IJ. et al, (2020), Nature, 585, 85 - 90

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.

Journal article

Malinauskas T. et al, (2020), Proceedings of the National Academy of Sciences of the United States of America, 117, 15620 - 15631

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.

Journal article

Dubey R. et al, (2020), eLife, 9

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Journal article

Rozbesky D. et al, (2019), Nature Communications, 10

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