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Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

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McGough IJ. et al, (2020), Nature

Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling.

Journal article

Kinnebrew M. et al, (2019), eLife, 8

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

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Rudolf AF. et al, (2019), Nat Chem Biol

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

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Chen S. et al, (2019), Proc Natl Acad Sci U S A, 116, 17470 - 17479

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

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Kowatsch C. et al, (2019), Curr Opin Struct Biol, 57, 204 - 214

Biochemical mechanisms of vertebrate hedgehog signaling.

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Kong JH. et al, (2019), Development (Cambridge, England), 146

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

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Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017

Cilia-Associated Oxysterols Activate Smoothened.

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Raleigh DR. et al, (2018), Mol Cell, 72, 316 - 327.e5

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.

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Byrne EF. et al, (2018), Curr Opin Cell Biol, 51, 81 - 88

Structural Basis for Growth Differentiation Factor 5 (GDF5) Signaling Inhibition by Repulsive Guidance Molecules (RGMs)

Conference paper

Malinauskas T. et al, (2018), BIOPHYSICAL JOURNAL, 114, 464A - 464A

A Calcium-Sensing Receptor (CASR) Mutation Causes Hypocalcemia by Disrupting a Transmembrane Salt Bridge that Modulates beta-arrestin Signaling.

Conference paper

Gorvin C. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S133 - S133

G protein-coupled receptor lipid interactions: Insights from molecular dynamics simulations

Conference paper

Hedger G. et al, (2017), EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 46, S376 - S376

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.

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Siebold C. et al, (2017), Trends Cell Biol, 27, 365 - 378

Molecular Dynamics Simulations of G-Protein Coupled Receptor Lipid Interactions

Other

Hedger G. et al, (2017), BIOPHYSICAL JOURNAL, 112, 386A - 386A

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