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Publications

Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family.

Coupland CE. et al, (2023), Curr Opin Struct Biol, 80

The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.

Siebold C. and Rohatgi R., (2023), Annu Rev Biochem

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.

Kinnebrew M. et al, (2022), Science advances, 8

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Coupland CE. et al, (2021), Molecular cell, 81, 5025 - 5038.e10

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Griffiths SC. et al, (2021), Nature Communications, 12

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.

Kinnebrew M. et al, (2021), eLife, 10

Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Ansell TB. et al, (2021), Journal of Chemical Theory and Computation, 17, 6548 - 6558

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

Griffiths S. et al, (2021)

Structure and Mechanism of Hedgehog Acyl Transferase

Coupland CE. et al, (2021)

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**

Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659

Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Ansell TB. et al, (2021)

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.

Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31

Cholesterol access in cellular membranes controls Hedgehog signaling.

Radhakrishnan A. et al, (2020), Nature chemical biology, 16, 1303 - 1313

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

McGough IJ. et al, (2020), Nature, 585, 85 - 90

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.

Malinauskas T. et al, (2020), Proceedings of the National Academy of Sciences of the United States of America, 117, 15620 - 15631

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.

Dubey R. et al, (2020), eLife, 9

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Rozbesky D. et al, (2019), Nature Communications, 10

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Kinnebrew M. et al, (2019), eLife, 8

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Rudolf AF. et al, (2019), Nature chemical biology, 15, 975 - 982

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