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Publications

Structural insights into Frizzled3 through nanobody modulators.

Hillier J. et al, (2024), Nat Commun, 15

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Pouwels KB. et al, (2024), Nature Communications, 15

Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain

Powell GT. et al, (2024), Science, 384, 573 - 579

Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.

Barnkob MB. et al, (2024), Nat Commun, 15

Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.

Barnkob MB. et al, (2024), Nat Commun, 15

Structure and function of Semaphorin-5A glycosaminoglycan interactions

Nagy GN. et al, (2024), Nature Communications, 15

Structural Analysis and Development of Notum Fragment Screening Hits.

Zhao Y. et al, (2022), ACS chemical neuroscience

The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs.

Jackson V. et al, (2022), Structure (London, England : 1993)

Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.

Walters LC. et al, (2022), Cell reports, 39

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Willis NJ. et al, (2022), Journal of medicinal chemistry

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.

Li D. et al, (2022), Commun Biol, 5

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status

Eyre DW. et al, (2021), Clinical Microbiology and Infection, 27, 1516.e7 - 1516.e14

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Flanagan DJ. et al, (2021), Nature

Small-molecule inhibitors of carboxylesterase Notum

Zhao Y. et al, (2021), Future Medicinal Chemistry

Notum Deacylates Octanoylated Ghrelin

Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Schwerd T. et al, (2020), Bone Research, 8

Caffeine inhibits Notum activity by binding at the catalytic pocket

Zhao Y. et al, (2020), Communications Biology, 3

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Zhao Y. et al, (2020), Nature Communications, 11

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.

Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5

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