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Publications

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

Jackson V. et al, (2020)

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Mahy W. et al, (2020), Journal of medicinal chemistry

Structural basis of semaphorin‐plexin cis interaction

Rozbesky D. et al, (2020), The EMBO Journal

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.

Rozbesky D. et al, (2020), Structure (London, England : 1993)

The guidance receptor plexin D1 is a mechanosensor in endothelial cells.

Mehta V. et al, (2020), Nature, 578, 290 - 295

Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum.

Zhao Y. et al, (2019), J Pineal Res

Cell guidance ligands, receptors and complexes - orchestrating signalling in time and space.

Rozbesky D. and Jones EY., (2019), Curr Opin Struct Biol, 61, 79 - 85

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

Barnkob MB. et al, (2019)

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.

Atkinson BN. et al, (2019), Bioorganic & medicinal chemistry letters

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

Chen S. et al, (2019), Proc Natl Acad Sci U S A, 116, 17470 - 17479

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.

van der Klaauw AA. et al, (2019), Cell

Designer protein delivers signal of choice.

Jones EY., (2019), Nature, 565, 165 - 166

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

Atkinson BN. et al, (2019), MedChemComm, 10, 1361 - 1369

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC. et al, (2018), Nat Commun, 9

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.

Gorvin CM. et al, (2018), Hum Mol Genet, 27, 3720 - 3733

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC. et al, (2018), Nat Commun, 9

Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.

Zhao Y. et al, (2018), FEBS Lett

Structural biology and the molecular mechanics of cell guidance signalling

Jones EY., (2018), FEBS OPEN BIO, 8, 57 - 57

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