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Publications

Structural Analysis and Development of Notum Fragment Screening Hits.

Zhao Y. et al, (2022), ACS chemical neuroscience

Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.

Walters LC. et al, (2022), Cell reports, 39

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Powell GT. et al, (2022)

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Willis NJ. et al, (2022), Journal of medicinal chemistry

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.

Li D. et al, (2022), Commun Biol, 5

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status

Eyre DW. et al, (2021), Clinical Microbiology and Infection, 27, 1516.e7 - 1516.e14

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Flanagan DJ. et al, (2021), Nature

Small-molecule inhibitors of carboxylesterase Notum

Zhao Y. et al, (2021), Future Medicinal Chemistry

Notum Deacylates Octanoylated Ghrelin

Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Schwerd T. et al, (2020), Bone Research, 8

Caffeine inhibits Notum activity by binding at the catalytic pocket

Zhao Y. et al, (2020), Communications Biology, 3

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Zhao Y. et al, (2020), Nature Communications, 11

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.

Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

Jackson V. et al, (2020)

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Mahy W. et al, (2020), Journal of medicinal chemistry

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.

Schwerd T. et al, (2020), Bone research, 8

Structural basis of semaphorin‐plexin cis interaction

Rozbesky D. et al, (2020), The EMBO Journal

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.

Rozbesky D. et al, (2020), Structure (London, England : 1993)

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