Structural Analysis and Development of Notum Fragment Screening Hits.
Journal article
Zhao Y. et al, (2022), ACS chemical neuroscience
Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.
Journal article
Walters LC. et al, (2022), Cell reports, 39
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Journal article
Willis NJ. et al, (2022), Journal of medicinal chemistry
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.
Journal article
Li D. et al, (2022), Commun Biol, 5
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Journal article
Steadman D. et al, (2021), Journal of Medicinal Chemistry
Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status
Journal article
Eyre DW. et al, (2021), Clinical Microbiology and Infection, 27, 1516.e7 - 1516.e14
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Journal article
Flanagan DJ. et al, (2021), Nature
Small-molecule inhibitors of carboxylesterase Notum
Journal article
Zhao Y. et al, (2021), Future Medicinal Chemistry
Notum Deacylates Octanoylated Ghrelin
Journal article
Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
Journal article
Schwerd T. et al, (2020), Bone Research, 8
Caffeine inhibits Notum activity by binding at the catalytic pocket
Journal article
Zhao Y. et al, (2020), Communications Biology, 3
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Journal article
Zhao Y. et al, (2020), Nature Communications, 11
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Journal article
Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5
The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs
Journal article
Jackson V. et al, (2020)
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
Journal article
Mahy W. et al, (2020), Journal of medicinal chemistry
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Journal article
Schwerd T. et al, (2020), Bone research, 8
Structural basis of semaphorin‐plexin cis interaction
Journal article
Rozbesky D. et al, (2020), The EMBO Journal
Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
Journal article
Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260
Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.
Journal article
Rozbesky D. et al, (2020), Structure (London, England : 1993)