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Publications

SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile

Zhang J-Y. et al, (2023), Genome Medicine, 15

Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis.

Kwok AJ. et al, (2023), Nat Immunol

Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Zhang J-Y. et al, (2022), Nature Communications, 13

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.

Sioofy-Khojine A-B. et al, (2022), Diabetologia

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

Trzupek D. et al, (2022), Wellcome Open Research, 6, 149 - 149

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach.

Richardson TG. et al, (2022), Nature communications, 13

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.

Mountjoy E. et al, (2021), Nat Genet, 53, 1527 - 1533

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

Downes DJ. et al, (2021), Nature Genetics, 53, 1606 - 1615

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.

Robertson CC. et al, (2021), Nature genetics

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

Trzupek D. et al, (2021), Wellcome Open Research, 6, 149 - 149

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Collier DA. et al, (2021), Nature, 593, 136 - 141

SARS-CoV-2 within-host diversity and transmission

Lythgoe KA. et al, (2021), Science, 372

Analysis of overlapping genetic association in type 1 and type 2 diabetes.

Inshaw JRJ. et al, (2021), Diabetologia

In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control

Ansari MA. et al, (2021), Wellcome Open Research, 6, 47 - 47

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Ghoussaini M. et al, (2021), Nucleic acids research, 49, D1311 - D1320

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

Arroyo Hornero R. et al, (2020), Communications Biology, 3

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Trzupek D. et al, (2020), Genome Medicine, 12

PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity.

Sidore C. et al, (2020), Multiple sclerosis (Houndmills, Basingstoke, England)

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95

Whole-genome sequencing of patients with rare diseases in a national health system.

Turro E. et al, (2020), Nature, 583, 96 - 102

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