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Updated protein domain annotation of the PARP protein family sheds new light on biological function.

Journal article

Suskiewicz MJ. et al, (2023), Nucleic acids research

Target 2035 – an update on private sector contributions

Journal article

Ackloo S. et al, (2023), RSC Medicinal Chemistry, 14, 1002 - 1011

An open source plant kinase chemogenomics set.

Journal article

Ercoli MF. et al, (2022), Plant direct, 6

Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.

Journal article

Scott F. et al, (2022), Bioorganic & medicinal chemistry letters, 60

Chemical Probes for Understudied Kinases: Challenges and Opportunities.

Journal article

Serafim RAM. et al, (2021), Journal of medicinal chemistry

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

Journal article

Serafim RAM. et al, (2021), Journal of medicinal chemistry

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Journal article

Henderson SH. et al, (2021), Journal of medicinal chemistry, 64, 11709 - 11728

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.

Journal article

Berger B-T. et al, (2021), Cell chemical biology, 28, 686 - 698.e7

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Journal article

Quevedo CE. et al, (2020), Bioorganic & medicinal chemistry, 28

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.

Journal article

Henderson SH. et al, (2020), ACS medicinal chemistry letters, 11, 1620 - 1626

Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.

Journal article

Asquith CRM. et al, (2020), ChemMedChem, 15, 1200 - 1215

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.

Journal article

Scott F. et al, (2020), Bioorganic & medicinal chemistry letters, 30

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.

Journal article

Wells C. et al, (2020), ACS medicinal chemistry letters, 11, 340 - 345

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Journal article

Asquith CRM. et al, (2019), Molecules (Basel, Switzerland), 24

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.

Journal article

de Toledo I. et al, (2019), The Journal of organic chemistry, 84, 14187 - 14201

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.

Journal article

Serafim RAM. et al, (2019), ACS medicinal chemistry letters, 10, 1266 - 1271

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.

Journal article

Alam MM. et al, (2019), Science (New York, N.Y.), 365

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