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Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
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Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors.
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Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
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Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Digles D. et al, (2024), Frontiers in pharmacology, 15
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
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Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.
Ji H. et al, (2023), Cell chemical biology
Open resources for chemical probes and their implications for future drug discovery
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Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments.
Martinelli P. et al, (2023), ChemMedChem
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
Coleman OD. et al, (2023), Chemical Science
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
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Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.
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DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.
Ketley RF. et al, (2022), Cell reports, 41
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity
Martin JG. et al, (2021), ChemBioChem, 22, 2116 - 2123
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia
Mackinnon SR. et al, (2021), ACS Chemical Biology, 16, 586 - 595
TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data
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