Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Tredup C. et al, (2024), RSC Med Chem
Covalent Inhibitors of KEAP1 with Exquisite Selectivity.
Fejes I. et al, (2024), Journal of medicinal chemistry
Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
Chen X. et al, (2024), JACS Au
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
Balıkçı E. et al, (2024), Journal of Medicinal Chemistry, 67, 7245 - 7259
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Digles D. et al, (2024), Frontiers in pharmacology, 15
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Raux B. et al, (2024), Bioorganic & medicinal chemistry letters, 98
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.
Ji H. et al, (2023), Cell chemical biology
Open resources for chemical probes and their implications for future drug discovery
Balıkçı E. et al, (2023), Expert Opinion on Drug Discovery, 18, 505 - 513
Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments.
Martinelli P. et al, (2023), ChemMedChem
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
Coleman OD. et al, (2023), Chemical Science
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Londregan AT. et al, (2023), Journal of medicinal chemistry, 66, 460 - 472
Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.
Rothweiler EM. and Huber KVM., (2023), Methods in molecular biology (Clifton, N.J.), 2706, 191 - 200
DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.
Ketley RF. et al, (2022), Cell reports, 41
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity
Martin JG. et al, (2021), ChemBioChem, 22, 2116 - 2123
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia
Mackinnon SR. et al, (2021), ACS Chemical Biology, 16, 586 - 595
TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data
Feyertag F. and Huber KVM., (2021)
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity
Pinto-Fernandez A. et al, (2021), British Journal of Cancer, 124, 817 - 830
Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.
Khan Tareque R. et al, (2020), ChemMedChem, 15, 2513 - 2520
Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.
Álvarez-Coiradas E. et al, (2020), International immunopharmacology, 89