Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Journal article

Raux B. et al, (2024), Bioorganic & medicinal chemistry letters, 98

Open resources for chemical probes and their implications for future drug discovery

Journal article

Balıkçı E. et al, (2023), Expert Opinion on Drug Discovery, 18, 505 - 513

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Journal article

Londregan AT. et al, (2023), Journal of medicinal chemistry, 66, 460 - 472

Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.

Journal article

Rothweiler EM. and Huber KVM., (2023), Methods in molecular biology (Clifton, N.J.), 2706, 191 - 200

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.

Journal article

Ketley RF. et al, (2022), Cell reports, 41

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Journal article

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

Journal article

Martin JG. et al, (2021), ChemBioChem, 22, 2116 - 2123

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

Journal article

Mackinnon SR. et al, (2021), ACS Chemical Biology, 16, 586 - 595

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

Journal article

Pinto-Fernandez A. et al, (2021), British Journal of Cancer, 124, 817 - 830

Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

Journal article

Álvarez-Coiradas E. et al, (2020), International immunopharmacology, 89

Quantifying CDK inhibitor selectivity in live cells.

Journal article

Wells CI. et al, (2020), Nature communications, 11

Quantifying Target Occupancy of Small Molecules Within Living Cells.

Journal article

Robers MB. et al, (2020), Annual review of biochemistry

Load More