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Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
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Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors.
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Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
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A live cell PRMT5 NanoBRETT target engagement assay querying competitive and uncompetitive modes of inhibition
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Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
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Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
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Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.
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Open resources for chemical probes and their implications for future drug discovery
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Discovery of a chemical probe to study implications of BPTF bromodomain inhibition in cellular and in vivo experiments.
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Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
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Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.
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DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.
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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
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Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity
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Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia
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