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Publications

Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Zhang J-Y. et al, (2022), Nature Communications, 13

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.

Dunger DB. et al, (2022), Trials, 23

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

Jarvis LB. et al, (2021), Commun Biol, 4

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.

Robertson CC. et al, (2021), Nature genetics

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

Trzupek D. et al, (2021), Wellcome Open Research, 6, 149 - 149

Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial

Marcovecchio ML. et al, (2020), Wellcome Open Research, 5, 49 - 49

Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial

Marcovecchio L. et al, (2020)

Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells.

Inshaw JRJ. et al, (2020), Diabetes care, 43, 169 - 177

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

Asimit JL. et al, (2019), Nature Communications, 10

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

Ferreira RC. et al, (2019), Frontiers in Immunology, 10

Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice.

Mattner J. et al, (2019), PLoS genetics, 15

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

Peterson LB. et al, (2018), Journal of Autoimmunity, 95, 1 - 14

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

Oliveira JJ. et al, (2018), Arthritis Research & Therapy, 20

The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes

Seelig E. et al, (2018), JCI Insight, 3

A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis

Huang W. et al, (2018), The Journal of Immunology, 200, 147 - 162

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Burren OS. et al, (2017), Genome Biology, 18

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Ferreira RC. et al, (2017), Journal of Autoimmunity, 84, 75 - 86

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial

Cutler AJ. et al, (2017), Wellcome Open Research, 2, 28 - 28

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2

Pekalski ML. et al, (2017), JCI Insight, 2

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial

Cutler AJ. et al, (2017), Wellcome Open Research, 2, 28 - 28

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