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Publications

A lower X-gate in TASK channels traps inhibitors within the vestibule

Rödström KEJ. et al, (2020), Nature, 582, 443 - 447

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.

Wang Q. et al, (2020), Structure (London, England : 1993), 28, 169 - 184.e5

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Bushell SR. et al, (2019), Nature Communications, 10

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.

Yu X. et al, (2019), eLife, 8

A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels

Schewe M. et al, (2019), Science, 363, 875 - 880

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Bushell SR. et al, (2018)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability

Spear ED. et al, (2018), Disease Models & Mechanisms

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Bradley AR. et al, (2017), Essays in Biochemistry, 61, 495 - 503

Asymmetric mechanosensitivity in a eukaryotic ion channel

Clausen MV. et al, (2017), Proceedings of the National Academy of Sciences, 114, E8343 - E8351

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

Aryal P. et al, (2017), Structure, 25, 708 - 718.e2

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

Wilkes M. et al, (2017), Nature Structural & Molecular Biology, 24, 123 - 130

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Grieben M. et al, (2017), Nature Structural & Molecular Biology, 24, 114 - 122

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

Mehmood S. et al, (2016), Nature Chemistry, 8, 1152 - 1158

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

Hresko RC. et al, (2016), Journal of Biological Chemistry, 291, 17271 - 17282

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

McClenaghan C. et al, (2016), Journal of General Physiology, 147, 497 - 505

An overview of heavy-atom derivatization of protein crystals

Pike ACW. et al, (2016), Acta Crystallographica Section D Structural Biology, 72, 303 - 318

Structures and functions of mitochondrial ABC transporters

Schaedler TA. et al, (2015), Biochemical Society Transactions, 43, 943 - 951

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

Stansfeld PJ. et al, (2015), Structure, 23, 1350 - 1361

ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione

Qiu W. et al, (2015), PLOS ONE, 10, e0129772 - e0129772

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Dong YY. et al, (2015), Science, 347, 1256 - 1259

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