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Publications

The RESOLUTE consortium: unlocking SLC transporters for drug discovery.

Superti-Furga G. et al, (2020), Nature reviews. Drug discovery, 19, 429 - 430

A lower X-gate in TASK channels traps inhibitors within the vestibule

Rodstrom KEJ. et al, (2020), NATURE

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Bushell SR. et al, (2019), Nature Communications, 10

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Fang H. et al, (2019), Nature Genetics, 51, 1082 - 1091

High-Throughput Site-Directed Mutagenesis.

Strain-Damerell C. and Burgess-Brown NA., (2019), Methods Mol Biol, 2025, 281 - 296

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

Dong YY. et al, (2018), Cell, 175, 1045 - 1058.e16

Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design

Dong YY. et al, (2018)

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.

Bulbrook D. et al, (2018), J Mol Biol, 430, 722 - 736

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Bradley AR. et al, (2017), Essays in Biochemistry, 61, 495 - 503

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

Tumber A. et al, (2017), Cell Chem Biol, 24, 371 - 380

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Grieben M. et al, (2017), Nature Structural & Molecular Biology, 24, 114 - 122

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

Johansson C. et al, (2016), Nat Chem Biol, 12, 539 - 545

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis

Montgomery AB. et al, (2016), ANNALS OF THE RHEUMATIC DISEASES, 75, 1255 - 1261

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.

Montgomery AB. et al, (2016), Ann Rheum Dis, 75, 1255 - 1261

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

Bavetsias V. et al, (2016), J Med Chem, 59, 1388 - 1409

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Dong YY. et al, (2015), Science, 347, 1256 - 1259

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

England KS. et al, (2014), Medchemcomm, 5, 1879 - 1886

A scintillation proximity assay for histone demethylases.

Yu W. et al, (2014), Anal Biochem, 463, 54 - 60

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.

Philpott M. et al, (2014), Epigenetics Chromatin, 7

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

Guetzoyan L. et al, (2014), MedChemComm, 5, 540 - 546

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