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The RESOLUTE consortium: unlocking SLC transporters for drug discovery.

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Superti-Furga G. et al, (2020), Nature reviews. Drug discovery, 19, 429 - 430

A lower X-gate in TASK channels traps inhibitors within the vestibule

Journal article

Rodstrom KEJ. et al, (2020), NATURE

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

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Bushell SR. et al, (2019), Nature Communications, 10

A genetics-led approach defines the drug target landscape of 30 immune-related traits

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Fang H. et al, (2019), Nature Genetics, 51, 1082 - 1091

High-Throughput Site-Directed Mutagenesis.

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Strain-Damerell C. and Burgess-Brown NA., (2019), Methods Mol Biol, 2025, 281 - 296

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

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Dong YY. et al, (2018), Cell, 175, 1045 - 1058.e16

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

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Grieben M. et al, (2017), Nature Structural & Molecular Biology, 24, 114 - 122

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

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Johansson C. et al, (2016), Nat Chem Biol, 12, 539 - 545

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis

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Montgomery AB. et al, (2016), ANNALS OF THE RHEUMATIC DISEASES, 75, 1255 - 1261

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

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Dong YY. et al, (2015), Science, 347, 1256 - 1259

A scintillation proximity assay for histone demethylases.

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Yu W. et al, (2014), Anal Biochem, 463, 54 - 60

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.

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Philpott M. et al, (2014), Epigenetics Chromatin, 7

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