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DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity

Journal article

Schröder M. et al, (2020), Journal of Medicinal Chemistry, 63, 10224 - 10234

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1

Journal article

Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

Journal article

Fagan V. et al, (2019), Journal of Medicinal Chemistry

Discovery of a potent and selective fragment-like inhibitor of SPIN1

Conference paper

Yan X. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258

Rapid covalent-probe discovery by electrophile-fragment screening.

Journal article

Resnick E. et al, (2019), J Am Chem Soc

A chemical toolbox for the study of bromodomains and epigenetic signaling.

Journal article

Wu Q. et al, (2019), Nat Commun, 10

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Journal article

Asquith CRM. et al, (2019), J Med Chem, 62, 2830 - 2836

Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.

Journal article

Christott T. et al, (2019), SLAS Discov, 24, 133 - 141

An Activity‐Based Probe Targeting Non‐Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

Journal article

D'Ascenzio M. et al, (2019), Angewandte Chemie International Edition, 58, 1007 - 1012

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Journal article

Vazquez‐Rodriguez S. et al, (2019), Angewandte Chemie International Edition, 58, 515 - 519

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Journal article

Hassell-Hart S. et al, (2019), Organometallics

Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).

Journal article

Heidenreich D. et al, (2018), J Med Chem, 61, 10929 - 10934

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

Journal article

Moustakim M. et al, (2018), Angew Chem Int Ed Engl, 57, 16302 - 16307

Development of a YEATS-domain chemical probe

Conference paper

Moustakim M. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256

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