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Publications

Emerging tools to investigate bromodomain functions

Kougnassoukou Tchara P-E. et al, (2020), Methods, 184, 40 - 52

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Louphrasitthiphol P. et al, (2020), Molecular Cell, 79, 472 - 487.e10

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

Chen Z. et al, (2020), Open Biology, 10, 200041 - 200041

Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells

Lines KE. et al, (2020), Endocrine-Related Cancer, 27, 163 - 174

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Hassell-Hart S. et al, (2020), ORGANOMETALLICS, 39, 408 - 416

A chemical toolbox for the study of bromodomains and epigenetic signaling

Wu Q. et al, (2019), Nature Communications, 10

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump NT. et al, (2019)

Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma

Song Y. et al, (2019), Leukemia, 33, 2685 - 2694

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

Chen Z. et al, (2019), Structure, 27, 1395 - 1404.e4

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

Marabelli C. et al, (2019), Cell Reports, 27, 387 - 399.e7

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

Ivanochko D. et al, (2019), Nucleic Acids Research, 47, 1225 - 1238

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Lambert J-P. et al, (2019), Molecular Cell, 73, 621 - 638.e17

Evaluation of linker length effects on a BET bromodomain probe

Traquete R. et al, (2019), Chemical Communications, 55, 10128 - 10131

A TFEB nuclear export signal integrates amino acid supply and glucose availability

Li L. et al, (2018), Nature Communications, 9

What Is the BET on Solid Tumors?

Filippakopoulos P., (2018), Journal of Clinical Oncology, 36, 3040 - 3042

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Ngeow KC. et al, (2018), Proceedings of the National Academy of Sciences, 115

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling

Hrdinka M. et al, (2018), The EMBO Journal, 37

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

Shiota H. et al, (2018), Cell Reports, 24, 3477 - 3487.e6

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

Jennings LE. et al, (2018), Bioorganic & Medicinal Chemistry, 26, 2937 - 2957

The C-terminal extension landscape of naturally presented HLA-I ligands

Guillaume P. et al, (2018), Proceedings of the National Academy of Sciences, 115, 5083 - 5088

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