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Emerging tools to investigate bromodomain functions

Kougnassoukou Tchara P-E. et al, (2020), Methods, 184, 40 - 52

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Louphrasitthiphol P. et al, (2020), Molecular Cell, 79, 472 - 487.e10

Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells

Lines KE. et al, (2020), Endocrine-Related Cancer, 27, 163 - 174

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Hassell-Hart S. et al, (2020), ORGANOMETALLICS, 39, 408 - 416

A chemical toolbox for the study of bromodomains and epigenetic signaling

Wu Q. et al, (2019), Nature Communications, 10

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

Chen Z. et al, (2019), Structure, 27, 1395 - 1404.e4

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

Marabelli C. et al, (2019), Cell Reports, 27, 387 - 399.e7

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Lambert J-P. et al, (2019), Molecular Cell, 73, 621 - 638.e17

Evaluation of linker length effects on a BET bromodomain probe

Traquete R. et al, (2019), Chemical Communications, 55, 10128 - 10131

What Is the BET on Solid Tumors?

Filippakopoulos P., (2018), Journal of Clinical Oncology, 36, 3040 - 3042

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Ngeow KC. et al, (2018), Proceedings of the National Academy of Sciences, 115

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

Shiota H. et al, (2018), Cell Reports, 24, 3477 - 3487.e6

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

Jennings LE. et al, (2018), Bioorganic & Medicinal Chemistry, 26, 2937 - 2957

The C-terminal extension landscape of naturally presented HLA-I ligands

Guillaume P. et al, (2018), Proceedings of the National Academy of Sciences, 115, 5083 - 5088

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