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Publications

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

Chen Z. et al, (2020), Open Biology, 10, 200041 - 200041

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Louphrasitthiphol P. et al, (2020), Molecular Cell

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

Chen Z. et al, (2020)

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump NT. et al, (2019)

Emerging tools to investigate bromodomain functions.

Kougnassoukou Tchara P-E. et al, (2019), Methods (San Diego, Calif.)

BRomoDomain-containing protein 4 (BRD4) regulates oxidative stress and autophagy in skeletal muscle

Segatto M. et al, (2019), ACTA PHYSIOLOGICA, 227, 7 - 8

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

Chen Z. et al, (2019), Structure, 27, 1395 - 1404.e4

A chemical toolbox for the study of bromodomains and epigenetic signaling.

Wu Q. et al, (2019), Nat Commun, 10

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex.

Marabelli C. et al, (2019), Cell Rep, 27, 387 - 399.e7

Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma.

Song Y. et al, (2019), Leukemia

Evaluation of linker length effects on a BET bromodomain probe

Traquete R. et al, (2019), Chemical Communications, 55, 10128 - 10131

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Hassell-Hart S. et al, (2019), Organometallics

Interactome rewiring following pharmacological targeting of BET bromodomains

Lamber J-P. et al, (2018), Molecular Cell

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

Ivanochko D. et al, (2018), Nucleic Acids Res

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

Hrdinka M. et al, (2018), EMBO J, 37

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC. et al, (2018), Proc Natl Acad Sci U S A

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

Jennings LE. et al, (2018), Bioorg Med Chem, 26, 2937 - 2957

A TFEB nuclear export signal integrates amino acid supply and glucose availability.

Li L. et al, (2018), Nat Commun, 9

What Is the BET on Solid Tumors?

Filippakopoulos P., (2018), J Clin Oncol

The C-terminal extension landscape of naturally presented HLA-I ligands.

Guillaume P. et al, (2018), Proc Natl Acad Sci U S A, 115, 5083 - 5088

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