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Publications

Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.

Du Y. et al, (2023), The Journal of biological chemistry

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

O'Brien DP. et al, (2023), Molecular & Cellular Proteomics, 22, 100609 - 100609

The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.

Fazazi MR. et al, (2023), Brain research bulletin

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Bashore FM. et al, (2023), bioRxiv

Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.

Du Y. et al, (2023), bioRxiv

Open drug discovery in Alzheimer's disease.

Axtman AD. et al, (2023), Alzheimer's & dementia (New York, N. Y.), 9

Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity

Fowkes MM. et al, (2023), Journal of Medicinal Chemistry

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors

Schuller M. et al, (2023), Pathogens, 12, 324 - 324

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.

Frank N. et al, (2022), Nature

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Imaging articular cartilage in osteoarthritis using targeted peptide radiocontrast agents.

Fowkes MM. et al, (2022), PloS one, 17

Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia

Mould AW. et al, (2022), CNS Drugs, 36, 1 - 16

Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening.

Mackinnon SR. et al, (2022), Frontiers in chemistry, 10

Target 2035-update on the quest for a probe for every protein

Mueller S. et al, (2021), RSC MEDICINAL CHEMISTRY

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Nizami S. et al, (2021), Scientific Reports, 11

Author Correction: A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Nizami S. et al, (2021), Scientific Reports, 11

The structural basis of fatty acid elongation by the ELOVL elongases

Nie L. et al, (2021), Nature Structural & Molecular Biology, 28, 512 - 520

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

Mackinnon SR. et al, (2021), ACS Chemical Biology, 16, 586 - 595

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity.

Doss PMIA. et al, (2021), Cell reports, 34

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Quinlan RBA. and Brennan PE., (2021), RSC Chemical Biology, 2, 759 - 795

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