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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Journal article

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia

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Mould AW. et al, (2022), CNS Drugs, 36, 1 - 16

Target 2035-update on the quest for a probe for every protein

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Mueller S. et al, (2021), RSC MEDICINAL CHEMISTRY

Combinatorial library screening for selective ADAMTS-5 peptide substrates to study aggrecanase activity

Conference paper

Fowkes MM. et al, (2021), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 102, A11 - A12

The structural basis of fatty acid elongation by the ELOVL elongases

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Nie L. et al, (2021), Nature Structural & Molecular Biology, 28, 512 - 520

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

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Mackinnon SR. et al, (2021), ACS Chemical Biology, 16, 586 - 595

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

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Quinlan RBA. and Brennan PE., (2021), RSC Chemical Biology, 2, 759 - 795

RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors.

Journal article

Thompson AP. et al, (2021), The Journal of biological chemistry, 296

The Discovery and Utility of Chemical Probes in Target Discovery Preface

Book

Brennan P. and Rodriguez SV., (2021), 16, V - VII

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Journal article

Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry, 295, 17973 - 17985

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Journal article

Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry, 295, 17973 - 17985

Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death

Journal article

Cottone L. et al, (2020), Cancer Research, 80, 4540 - 4551

TargetDB: A target information aggregation tool and tractability predictor

Journal article

De Cesco S. et al, (2020), PLOS ONE, 15, e0232644 - e0232644

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