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The structural basis of fatty acid elongation by the ELOVL elongases

Journal article

Nie L. et al, (2021), Nature Structural & Molecular Biology, 28, 512 - 520

RHO to the DOCK for GDP disembarking: structural insights into the DOCK GTPase nucleotide exchange factors.

Journal article

Thompson AP. et al, (2021), The Journal of biological chemistry

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Journal article

Quinlan RBA. and Brennan PE., (2021), RSC Chemical Biology

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Journal article

Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry, 295, 17973 - 17985

The Discovery and Utility of Chemical Probes in Target Discovery

Book

Brennan P. and Vazquez-Rodriguez S., (2020)

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

Journal article

Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry

TargetDB: A target information aggregation tool and tractability predictor

Journal article

De Cesco S. et al, (2020), PLOS ONE, 15, e0232644 - e0232644

Inhibitors of JmjC-Containing Histone Demethylases

Chapter

Wright M. et al, (2020), Topics in Medicinal Chemistry, 33, 221 - 253

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1

Journal article

Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

Journal article

Fagan V. et al, (2019), Journal of Medicinal Chemistry

Discovery of a potent and selective fragment-like inhibitor of SPIN1

Conference paper

Yan X. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Journal article

Fang H. et al, (2019), Nature Genetics, 51, 1082 - 1091

Open science medicinal chemistry: Towards a treatment for DIPG

Conference paper

Cramp S. et al, (2019), CANCER RESEARCH, 79

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