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Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.

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Vilema-Enríquez G. et al, (2020), The Journal of biological chemistry

TargetDB: A target information aggregation tool and tractability predictor

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De Cesco S. et al, (2020), PLOS ONE, 15, e0232644 - e0232644

Inhibitors of JmjC-Containing Histone Demethylases

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Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1

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Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

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Fagan V. et al, (2019), Journal of Medicinal Chemistry

Discovery of a potent and selective fragment-like inhibitor of SPIN1

Conference paper

Yan X. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258

A genetics-led approach defines the drug target landscape of 30 immune-related traits

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Fang H. et al, (2019), Nature Genetics, 51, 1082 - 1091

Open science medicinal chemistry: Towards a treatment for DIPG

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Cramp S. et al, (2019), CANCER RESEARCH, 79

Rapid covalent-probe discovery by electrophile-fragment screening.

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Resnick E. et al, (2019), J Am Chem Soc

A chemical toolbox for the study of bromodomains and epigenetic signaling.

Journal article

Wu Q. et al, (2019), Nat Commun, 10

SuCOS: A pharmacophoric-shape overlap metric for comparing binding modes

Conference paper

Leung S. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 257

Targeting the Small GTPase Superfamily through their Regulatory Proteins.

Journal article

Gray JL. et al, (2019), Angew Chem Int Ed Engl

An Activity‐Based Probe Targeting Non‐Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

Journal article

D'Ascenzio M. et al, (2019), Angewandte Chemie International Edition, 58, 1007 - 1012

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