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Can we predict T cell specificity with digital biology and machine learning?

Journal article

Hudson D. et al, (2023), Nature reviews. Immunology, 23, 511 - 521

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.

Journal article

Yang X. et al, (2022), Nature, 612, 771 - 777

Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC.

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Sušac L. et al, (2022), Cell, 185, 3201 - 3213.e19

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.

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Lanz TV. et al, (2022), Nature, 603, 321 - 327

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.

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Theruvath J. et al, (2022), Nature medicine, 28, 333 - 344

RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development

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Wang J. et al, (2021), Cell, 184, 5869 - 5885.e25

Immune receptor inhibition through enforced phosphatase recruitment

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Fernandes RA. et al, (2020), Nature, 586, 779 - 784

A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions

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Wojtowicz WM. et al, (2020), Cell, 182, 1027 - 1043.e17

Opposing T cell responses in experimental autoimmune encephalomyelitis

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Saligrama N. et al, (2019), Nature, 572, 481 - 487

A cell topography-based mechanism for ligand discrimination by the T cell receptor

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Fernandes RA. et al, (2019), Proceedings of the National Academy of Sciences, 116, 14002 - 14010

Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro

Journal article

Gee MH. et al, (2018), Proceedings of the National Academy of Sciences, 115

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

Journal article

Sibener LV. et al, (2018), Cell, 174, 672 - 687.e27

Capturing resting T cells: the perils of PLL

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Santos AM. et al, (2018), Nature Immunology, 19, 203 - 205

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes

Journal article

Gee MH. et al, (2018), Cell, 172, 549 - 563.e16

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

Journal article

Carbone CB. et al, (2017), Proceedings of the National Academy of Sciences, 114

Snapin promotes HIV ‐1 transmission from dendritic cells by dampening TLR 8 signaling

Journal article

Khatamzas E. et al, (2017), The EMBO Journal, 36, 2998 - 3011

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