Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.
Rodriguez-Meira A. et al, (2023), Nat Genet
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis
Mirman Z. et al, (2022), Nature Cell Biology, 24, 51 - 61
BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination
Becker JR. et al, (2021), Nature, 596, 433 - 437
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
Hewitt G. et al, (2021), Molecular Cell, 81, 767 - 783.e11
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Yeow ZY. et al, (2020), Nature, 585, 447 - 452
Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.
Francica P. et al, (2020), Cell reports, 32
An essential role for the Zn2+ transporter ZIP7 in B cell development
Anzilotti C. et al, (2019), Nature Immunology, 20, 350 - 361
H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids
Nakamura K. et al, (2019), Nature Cell Biology, 21, 311 - 318
H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids
Nakamura K. et al, (2019), NATURE CELL BIOLOGY, 21, 311 - +
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity
Becker JR. et al, (2018), Nature Communications, 9
53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ
Ghezraoui H. et al, (2018), Nature, 560, 122 - 127
Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein
Botuyan MV. et al, (2018), Nature Structural & Molecular Biology, 25, 591 - 600
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
Altemose N. et al, (2017), eLife, 6
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
Altemose N. et al, (2017), ELIFE, 6
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.
Wright DJ. et al, (2017), Nat Genet, 49, 674 - 679
53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms.
Cuella-Martin R. et al, (2016), Mol Cell, 64, 51 - 64
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Day FR. et al, (2015), Nature Genetics, 47, 1294 - 1303
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Xu G. et al, (2015), Nature, 521, 541 - 544