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Publications

53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis

Mirman Z. et al, (2022), Nature Cell Biology, 24, 51 - 61

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

Becker JR. et al, (2021), Nature, 596, 433 - 437

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Hewitt G. et al, (2021), Molecular Cell, 81, 767 - 783.e11

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

Yeow ZY. et al, (2020), Nature, 585, 447 - 452

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

Francica P. et al, (2020), Cell reports, 32

BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination

Becker JR. et al, (2020)

An essential role for the Zn2+ transporter ZIP7 in B cell development

Anzilotti C. et al, (2019), Nature Immunology, 20, 350 - 361

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

Nakamura K. et al, (2019), Nature Cell Biology, 21, 311 - 318

H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

Nakamura K. et al, (2019), NATURE CELL BIOLOGY, 21, 311 - +

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

Becker JR. et al, (2018), Nature Communications, 9

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

Ghezraoui H. et al, (2018), Nature, 560, 122 - 127

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

Botuyan MV. et al, (2018), Nature Structural & Molecular Biology, 25, 591 - 600

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

Altemose N. et al, (2017), eLife, 6

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

Altemose N. et al, (2017), ELIFE, 6

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

Wright DJ. et al, (2017), Nat Genet, 49, 674 - 679

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms.

Cuella-Martin R. et al, (2016), Mol Cell, 64, 51 - 64

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Day FR. et al, (2015), Nature Genetics, 47, 1294 - 1303

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Xu G. et al, (2015), Nature, 521, 541 - 544

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

Chapman JR. et al, (2013), Mol Cell, 49, 858 - 871

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