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Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

Journal article

Gerken PA. et al, (2017), Angewandte Chemie International Edition, 56, 15555 - 15559

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.

Journal article

Forment JV. et al, (2017), Nat Chem Biol, 13, 12 - 14

Comparison of genetic variants in matched samples using thesaurus annotation.

Journal article

Konopka T. and Nijman SMB., (2016), Bioinformatics, 32, 657 - 663

A generic strategy for CRISPR-Cas9-mediated gene tagging.

Journal article

Lackner DH. et al, (2015), Nat Commun, 6

Functional genomics to uncover drug mechanism of action.

Journal article

Nijman SMB., (2015), Nat Chem Biol, 11, 942 - 948

Light-assisted small-molecule screening against protein kinases.

Journal article

Inglés-Prieto Á. et al, (2015), Nat Chem Biol, 11, 952 - 954

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.

Journal article

Licciardello MP. et al, (2015), Oncogene, 34, 3780 - 3790

A thesaurus of genetic variation for interrogation of repetitive genomic regions.

Journal article

Kerzendorfer C. et al, (2015), Nucleic Acids Res, 43

Targeting a cell state common to triple-negative breast cancers.

Journal article

Muellner MK. et al, (2015), Mol Syst Biol, 11

Synthetic lethal vulnerabilities of cancer.

Journal article

Fece de la Cruz F. et al, (2015), Annu Rev Pharmacol Toxicol, 55, 513 - 531

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

Journal article

Essletzbichler P. et al, (2014), Genome Res, 24, 2059 - 2065

Exploiting epigenetic vulnerabilities for cancer therapeutics.

Journal article

Mair B. et al, (2014), Trends Pharmacol Sci, 35, 136 - 145

Cancer. Potential of the synthetic lethality principle.

Journal article

Nijman SMB. and Friend SH., (2013), Science, 342, 809 - 811

A reversible gene trap collection empowers haploid genetics in human cells.

Journal article

Bürckstümmer T. et al, (2013), Nat Methods, 10, 965 - 971

A Functional Pharmacogenetic Screen in Non-small Cell Lung Adenocarcinoma

Conference paper

de la Cruz FF. et al, (2012), EUROPEAN JOURNAL OF CANCER, 48, S234 - S234

Functional drug-gene interactions in lung cancer.

Journal article

Smida M. and Nijman SMB., (2012), Expert Rev Mol Diagn, 12, 291 - 302

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