Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Journal article
Leach JDG. et al, (2021), Nature communications, 12
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Journal article
Flanagan DJ. et al, (2021), Nature
A pilot study on automatic 3D quantification of Barrett’s esophagus for risk stratification and therapy monitoring
Journal article
Ali S. et al, (2021), Gastroenterology
BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration.
Journal article
Koppens MA. et al, (2021), Gastroenterology
Advances in colon cancer research: in vitro and animal models
Journal article
Lannagan TR. et al, (2021), Current Opinion in Genetics and Development, 66, 50 - 56
The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis.
Journal article
Kobayashi H. et al, (2020), Gastroenterology
Melanoma cell adhesion molecule defines a proliferative subset of leptin receptor-lineage cells that substantially contribute to the colorectal cancer stroma
Conference paper
Gieniec K. et al, (2020), JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35, 163 - 163
Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer.
Conference paper
Nowinski S. et al, (2020), CANCER RESEARCH, 80
Stromal imbalance of bone morphogenetic protein signaling drives colorectal carcinogenesis
Conference paper
Kobayashi H. et al, (2020), JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35, 160 - 160
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals
Journal article
Demetriou P. et al, (2020), Nature Immunology, 21, 1232 - 1243
Gremlin 1 - small protein, big impact: the multiorgan consequences of disrupted BMP antagonism†.
Journal article
Gooding S. and Leedham SJ., (2020), The Journal of pathology, 251, 349 - 352
GENERATION OF A GASTRIC ADENOCARCINOMA AND PROXIMAL POLYPOSIS OF THE STOMACH (GAPPS) MOUSE THAT PHENOCOPIES HUMAN DISEASE
Conference paper
Suzuki N. et al, (2020), GASTROENTEROLOGY, 158, S160 - S160
Reserving the Right to Change the Intestinal Stem Cell Model
Journal article
Leedham SJ., (2020), Cell Stem Cell, 26, 301 - 302
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Journal article
Serra EG. et al, (2020), Nature communications, 11
Intestine, Heal Thyself! Regulating the Intestinal Epithelial Response to Injury.
Journal article
Leedham SJ., (2020), Cellular and molecular gastroenterology and hepatology
Remission of Inflammatory Bowel Disease in Glucose-6-Phosphatase 3 Deficiency by Allogeneic Haematopoietic Stem Cell Transplantation
Journal article
Bolton C. et al, (2020), Journal of Crohn's and Colitis, 14, 142 - 147
Deciphering the molecular signalling underpinning early-dissemination and metastasis from stage I colorectal cancer
Conference paper
Dunne P. et al, (2019), BRITISH JOURNAL OF CANCER, 121, 4 - 4
Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification
Journal article
Kleeman SO. et al, (2019), Gut
The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.
Journal article
Thomas R. et al, (2019), Scientific reports, 9
A Quantitative Evolutionary Approach Utilising High Resolution Chromosomal Copy Number Analysis Accurately Stratifies Patients with Ulcerative Colitis and Low Grade Dysplasia by Future Colorectal Cancer Risk
Conference paper
Al Bakir I. et al, (2019), JOURNAL OF PATHOLOGY, 249, S12 - S12