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Publications

Immunosuppressive niche engineering at the onset of human colorectal cancer.

Gatenbee CD. et al, (2022), Nat Commun, 13

Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models.

Schenck RO. et al, (2022), Molecular biology and evolution

Germline variant testing in Serrated Polyposis Syndrome.

Murphy A. et al, (2022), Journal of gastroenterology and hepatology

The molecular subtyping resource (MouSR): a user-friendly tool for rapid biological discovery from transcriptional data.

Ahmaderaghi B. et al, (2022), Disease models & mechanisms

Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues

Gabbutt C. et al, (2022), Nature Biotechnology

The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.

Kobayashi H. et al, (2021), Gastroenterology

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

Heino S. et al, (2021), Science Advances, 7

Morphogen regulation of stem cell plasticity in intestinal regeneration and carcinogenesis.

Eggington HR. et al, (2021), Dev Dyn

A Pilot Study on Automatic Three-Dimensional Quantification of Barrett’s Esophagus for Risk Stratification and Therapy Monitoring

Ali S. et al, (2021), Gastroenterology, 161, 865 - 878.e8

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

Leach JDG. et al, (2021), Nature communications, 12

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Flanagan DJ. et al, (2021), Nature

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration.

Koppens MA. et al, (2021), Gastroenterology

Advances in colon cancer research: in vitro and animal models

Lannagan TR. et al, (2021), Current Opinion in Genetics and Development, 66, 50 - 56

The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis.

Kobayashi H. et al, (2020), Gastroenterology

Melanoma cell adhesion molecule defines a proliferative subset of leptin receptor-lineage cells that substantially contribute to the colorectal cancer stroma

Gieniec K. et al, (2020), JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35, 163 - 163

Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer.

Nowinski S. et al, (2020), CANCER RESEARCH, 80

Stromal imbalance of bone morphogenetic protein signaling drives colorectal carcinogenesis

Kobayashi H. et al, (2020), JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35, 160 - 160

A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Demetriou P. et al, (2020), Nature Immunology, 21, 1232 - 1243

Gremlin 1 - small protein, big impact: the multiorgan consequences of disrupted BMP antagonism†.

Gooding S. and Leedham SJ., (2020), The Journal of pathology, 251, 349 - 352

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman SO. et al, (2020), Gut, 69, 1092 - 1103

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