Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation
Hosseini A. et al, (2025), Nature
20 years of histone lysine demethylases: From discovery to the clinic and beyond.
Gray ZH. et al, (2025), Cell, 188, 1747 - 1783
An E2 ubiquitin-conjugating enzyme links diubiquitinated H2B to H3K27M oncohistone function.
Jiao AL. et al, (2024), Proceedings of the National Academy of Sciences of the United States of America, 121
WNT signalling control by KDM5C during development affects cognition.
Karwacki-Neisius V. et al, (2024), Nature
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Zhang G. et al, (2023), Mol Cell
METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells.
Mu M. et al, (2023), Cell reports, 42
RNA m6A methylation across the transcriptome.
Sendinc E. and Shi Y., (2023), Mol Cell, 83, 428 - 441
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2.
Zhou C. et al, (2022), Cell discovery, 8
BAF complex maintains glioma stem cells in pediatric H3K27M-glioma.
Panditharatna E. et al, (2022), Cancer discovery
Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4.
Luo Q. et al, (2022), Nat Commun, 13
STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.
Chu Z. et al, (2022), Nature communications, 13
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis.
Xu W. et al, (2022), Mol Cell
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.
Liu Y. et al, (2021), Nature communications, 12
Chromatin-state barriers enforce an irreversible mammalian cell fate decision
Blanco MA. et al, (2021), Cell Reports, 37, 109967 - 109967
Simultaneous Inhibition of LSD1 and TGFβ Enables Eradication of Poorly Immunogenic Tumors with Anti-PD-1 Treatment.
Sheng W. et al, (2021), Cancer discovery, 11, 1970 - 1981
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
Zee BM. et al, (2021), iScience, 24
The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Stielow B. et al, (2021), Science advances, 7
Nucleotide resolution profiling of m3C RNA modification by HAC-seq
Cui J. et al, (2021), Nucleic Acids Research, 49, e27 - e27
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Xu W. et al, (2021), Nature, 591, 317 - 321
meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation.
Mikutis S. et al, (2020), ACS central science, 6, 2196 - 2208