Sir Henry Wellcome Postdoctoral Fellow - Clinical Immunology
I am a Postdoctoral Immunologist working with Simon Draper in the Blood Stage Malaria Vaccine Programme. My research focuses on establishing methodologies to isolate antigen-specific human B cells and follicular helper (Tfh) T cells from peripheral blood, with a particular interest in the cellular immunology kinetics post-vaccination with malaria candidate vaccine PfRH5. This work also aims to facilitate high-throughput monoclonal antibody generation, B cell repertoire analysis, and single cell analyses of Tfh cells.
Prior to joining the Jenner Institute, I obtained my ScM in Molecular Microbiology and Immunology at the Johns Hopkins School of Public Health, before completing my PhD with Eleanor Riley at the London School of Hygiene and Tropical Medicine. My PhD thesis work, supported by an MRC Vaccine Research studentship, focused on the impact of human cytomegalovirus infection on natural killer cell responses to vaccines.
My long-term interest is in understanding the factors that contribute to heterogeneity in vaccine immunogenicity and efficacy, in order to guide vaccine development and optimisation.
Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine
Nielsen CM. et al, (2023), JCI Insight, 8
Impact of a blood-stage vaccine on Plasmodium vivax malaria
Hou MM. et al, (2022)
Delayed booster dosing improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine
Nielsen CM. et al, (2022)
Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly
Minassian AM. et al, (2021), JCI Insight, 6
Malaria Vaccines: Recent Advances and New Horizons
Draper SJ. et al, (2018), Cell Host & Microbe, 24, 43 - 56