Colleges
Chris Garrard
Dr, Clinical Lecturer in Intensive Care
UK Critical Care Genomics (UKCCG) A consortium of 30 UK Intensive Care Units collaborating in genomic studies of host response to severe life threatening infection. Leads: Dr CS Garrard (NDM) and Prof Charles Hinds (St Bartholomew's Hospital, London) see: http://www.ukccg-gains.org/
UKCCG currently participating in 2 large, multi-centre genome association studies in the UK (Genomic Advances in Sepsis - GAinS) and in Europe (Genetics of Sepsis - GenOSept). Funded by the Sainsbury Charitable Fund and 6th Framework programme of Research and Development - European Union) these studies are actively recruiting patients with sepsis syndrome admitted to Intensive Care Units in the UK and Europe with admission diagnoses of community acquired pneumonia, faecal peritonitis (GAinS) pancreatitis or meningococcal disease (GenOSept). See also: https://clinicaltrials.gov/
Recent publications
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Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis
Journal article
Tridente A. et al, (2017), Annals of Intensive Care, 7
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Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia
Journal article
Burnham KL. et al, (2017), American Journal of Respiratory and Critical Care Medicine, 196, 328 - 339
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Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study
Journal article
Davenport EE. et al, (2016), The Lancet Respiratory Medicine, 4, 259 - 271
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Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort
Journal article
Tridente A. et al, (2015), Critical Care, 19
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Variants in the Mannose-binding Lectin GeneMBL2do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort
Journal article
Mills TC. et al, (2015), Clinical Infectious Diseases, 61, 695 - 703