David Church
Professor
- Cancer Research UK Senior Cancer Research Fellow
- Honorary Consultant in Medical Oncology
Research focus
We study the mechanisms underpinning the growth and suppression of bowel and womb cancers, focusing particularly on the immune response tumours induce and evade. We aim to identify new biomarkers and targets to better prevent and treat these common diseases
Key publications
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Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study.
Journal article
Wagner SJ. et al, (2023), Cancer cell, 41, 1650 - 1661.e4
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POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer
Journal article
van Gool IC. et al, (2015), Clinical Cancer Research, 21, 3347 - 3355
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Screening for Lynch syndrome and referral to clinical genetics by selective mismatch repair protein immunohistochemistry testing: an audit and cost analysis
Journal article
Colling R. et al, (2015), Journal of Clinical Pathology, 68, 1036 - 1039
Recent publications
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Spatiotemporal immune landscape and long-term immune memory in POLE-mutant endometrial cancer at the single-cell level
Journal article
Brummel K. et al, (2025), Cancer Immunology Research
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Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers
Journal article
Ward JC. et al, (2025), Genome Medicine, 17
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Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner.
Journal article
Wiley MB. et al, (2025), Scientific reports, 15