David Pulido-Gomez
Senior Project Manager
Research
I obtained my PhD in Biochemistry and Molecular Biology at the Autonomous University of Barcelona. During my early research years I studied the innate immune system as a source of novel antibiotics, using the antimicrobial structural determinants of the human ribonucleases to develop new therapeutic agents.
After my PhD I moved to Imperial College London as a Postdoctoral Scientist in Professor Hohenester's Laboratory, where I expanded my knowledge and skills in protein production, structural biology and biophysics, especially in X-ray crystallography.
After my first postdoctoral experience I moved to the Structural Genomics Consortium, University of Oxford, where I consolidated myself as a structural biologist and protein production expert, developing novel drugs against autophagy regulators.
Currently, I am a Senior Postdoctoral Scientist working in Professor Simon J Draper's laboratory at the Jenner Institute, University of Oxford. My work is focused in the identification of improved antigen targets within the blood-stage merozoite malaria parasite; and the development and production of structure-guided protein based vaccines according to GMP standards.
Recent publications
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Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.
Journal article
King LDW. et al, (2024), Cell reports. Medicine, 5
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Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial
Journal article
Silk SE. et al, (2024), The Lancet Infectious Diseases
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Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies
Journal article
Alanine DGW. et al, (2019), Cell, 178, 216 - 228.e21
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Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1
Journal article
Pulido D. et al, (2018), Structure, 26, 1384 - 1392.e3
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Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides
Journal article
Pulido D. et al, (2018), European Journal of Medicinal Chemistry, 152, 590 - 599