Principal Investigator, Membrane Protein Structural and Chemical Biology
David Sauer is a biophysicist focusing on the structure and function of membrane channels and transporters. As group leader at the University of Oxford since 2021, he has been studying the structure and function of membrane proteins for 16 years. David completed his graduate degree studying potassium channel structure and ion selectivity with Youxing Jiang at the University of Texas Southwestern Medical Center. This was followed by postdoctoral training with Da-Neng Wang at New York University School of Medicine. There he described the structure, transport mechanism, and chemical inhibition of SLC13/DASS membrane transporters.
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Brawley DN. et al, (2022), Nature chemical biology
The ups and downs of elevator-type di-/tricarboxylate membrane transporters.
Sauer DB. et al, (2022), The FEBS journal, 289, 1515 - 1523