Dimitra Peppa
Research groups
Dimitra Peppa
Dr
MRC Clinician Scientist Dr, Group Head/PI, Consultant HIV Physician
Medical Research Council Clinician Scientist Fellowship -
'Natural Killer cell regulation of antiviral T cell responses in the pathogenesis of HIV infection'
My research interests focus on the role of NK cells in HIV immunopathogenesis and regulation of adaptive responses. Our work aims to delineate the role of genetic and environmental factors, such as HCMV, on shaping NK cell function and any downstream effects on adaptive immunity. I have previously demonstrated that NK cells play a crucial regulatory role during persistent Hepatitis B virus infection, involving deletion of virus specific cells. We continue to explore the relevance of this phenomenon in HIV infection given the importance of ongoing immune activation and predilection of NK cells for activated T cells. Our main research goal is to optimise, direct, or specifically target NK cells in therapeutic and preventative interventions that will allow us to overcome the current barriers to eliciting effective immunity to HIV.
Recent publications
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Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in a patient with uncontrolled HIV.
Journal article
Touizer E. et al, (2021), The lancet. HIV, 8, e317 - e318
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Seeing SARS-CoV-2 variants through the eyes of T cells.
Journal article
Alrubayyi A. and Peppa D., (2021), Nature reviews. Immunology, 21
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Dynamics of Transforming Growth Factor (TGF)-β Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines
Journal article
Dickinson M. et al, (2020), Frontiers in Immunology, 11
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Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report.
Journal article
Gupta RK. et al, (2020), The lancet. HIV, 7, e340 - e347
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Shared immunotherapeutic approaches in HIV and hepatitis B virus: combine and conquer.
Journal article
Maini MK. and Peppa D., (2020), Current opinion in HIV and AIDS, 15, 157 - 164
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Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin
Journal article
Cubero EM. et al, (2020), Frontiers in Immunology, 11
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Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection.
Journal article
Alrubayyi A. et al, (2020), Frontiers in cellular and infection microbiology, 10
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IL-15 re-programming compensates for NK cell mitochondrial dysfunction in HIV-1 infection
Internet publication
Cubero EM. et al, (2019)
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GENE ONTOLOGY ENRICHMENT AND INGENUITY PATHWAY ANALYSIS REVEALS DIFFERENTIALLY IMMUNE REGULATED NETWORKS IN TREATED COMPARED TO UNTREATED CHRONIC HEPATITIS B PATIENTS.
Conference paper
Gill US. et al, (2019), HEPATOLOGY, 70, 609A - 609A
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Entering a new era of harnessing natural killer cell responses in HIV infection
Journal article
Peppa D., (2019), EBioMedicine, 44, 26 - 27