Professor Guy Thwaites
Contact information
Podcast interview
Tuberculosis meningitis
Tuberculosis meningitis affects a fractions of TB patients but causes high levels of mortality and morbidity. A recent trial at OUCRU showed that aspirin can greatly improve outcomes. Such trial is typical of the work done in our Vietnam units, where all the research is focussed on improving the outcome for patients directly.
Colleges
Guy Thwaites
Professor of Infectious Diseases
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has a global research focus on life-threatening infections, especially tuberculosis and tuberculous meningitis, aiming to translate high-quality clinical trials and mechanistic science into better outcomes and policy. Guy lived and worked in southeast Asia for 17 years. He was Director of the Oxford University Clinical Research Unit (OUCRU), a Wellcome Trust Major International Programme, from October 2013 to January 2026. OUCRU conducts interdisciplinary research across Vietnam, Indonesia, and Nepal. Guy has spent the last 20 years building and leading large international teams and partnerships spanning governments, hospitals, WHO, and industry. He was appointed MBE for services to public health and Vietnam–UK relations in 2021, and is a Fellow of the Academy of Medical Sciences.
Recent publications
A randomised comparison of management strategies for drug-induced liver injury associated with tuberculous meningitis treatment
Journal article
Donovan J. et al, (2026), Journal of Infection, 93, 106796 - 106796
Unravelling HCV diversity and resistance in Viet Nam: a cross-sectional analysis
Journal article
Le Ngoc C. et al, (2026), The Lancet Regional Health - Western Pacific, 73, 101956 - 101956
The cause, treatment and outcome of hyponatraemia associated with tuberculous meningitis: An observational study nested within two clinical trials of corticosteroids
Journal article
Donovan J. et al, (2026), Journal of Infection, 93, 106763 - 106763
Transmission of rifampicin-resistant tuberculosis in Ho Chi Minh City, Viet Nam: a prospective genomic epidemiology study
Journal article
Spies R. et al, (2026), The Lancet Regional Health - Western Pacific, 71, 101906 - 101906
The Utility of a Three-gene Host Response to Discriminate Tuberculous Meningitis From Other Infections in Children
Journal article
Huynh J. et al, (2026), Pediatric Infectious Disease Journal, 45, 466 - 474