Colleges
Ian Tomlinson
Professor of Molecular and Population Genetics
- The identification of genes that predispose to colorectal and other cancers
- Functional genetics of colorectal tumorigenesis, with emphasis on the relative importance of selection and genomic instability.
- Cancer genes and metabolism.
- Cancer evolution.
Recent publications
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Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer.
Journal article
Nowak M. et al, (2024), Cell reports. Medicine, 5
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The PS4-likelihood ratio calculator: flexible allocation of evidence weighting for case-control data in variant classification.
Journal article
Rowlands CF. et al, (2024), Journal of medical genetics
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The genomic landscape of 2,023 colorectal cancers.
Journal article
Cornish AJ. et al, (2024), Nature
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Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors.
Journal article
Domingo E. et al, (2024), EBioMedicine, 106
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Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.
Journal article
Mahmood U. et al, (2024), Cancer research communications, 4, 1765 - 1776