Obstructive sleep apnoea (OSA):-
- Cardiovascular consequences of OSA
- Clinical mangement
Current main project is a multicentre trial of CPAP in patients with OSA and diabetic macular oedema, funded by the ResMed foundation. In addition we have used a CPAP withdrawal model to look at oxidative stress in OSA, funded by British Heart Foundation. A cross-sectional study of ventilatory failure in obesity has been recently completed. The CPAP withdrawal model is being used to look at vascular reactivity in the eye and the relevance of intermittent hypoxia to the cardiovascular effects in OSA.
Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial.
Wimms AJ. et al, (2020), The Lancet. Respiratory medicine, 8, 349 - 358
Effects of suboptimal adherence of CPAP therapy on symptoms of obstructive sleep apnoea: a randomised, double-blind, controlled trial.
Gaisl T. et al, (2020), The European respiratory journal, 55
Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea
Turnbull CD. et al, (2020), American Journal of Respiratory and Critical Care Medicine, 201, 247 - 250
Return of sleep apnoea and sleep fragmentation following CPAP withdrawal in patients with obstructive sleep apnoea.
Turnbull C. et al, (2019), The European respiratory journal, 53
Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials.
Crook S. et al, (2019), Thorax, 74, 390 - 396