Contact information
NDM Collaborators
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Richard Cornall
Nuffield Professor of Clinical Medicine and Head of Department
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John Todd
Professor of Precision Medicine
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Roman Fischer
Associate Professor and Head of Discovery Proteomics Facility
Colleges
Katherine Bull
Clinician Scientist
Oxford Kidney Pathology Group
Dr Katherine Bull is a group leader in the Centre for Human Genetics and Honorary Consultant Nephrologist in the Oxford Kidney Unit. She previously held an MRC-Kidney Research UK Professor David Kerr Clinician Scientist fellowship.
Outline of Research
The development of new therapies for kidney disease is hampered by limited understanding of the underlying mechanistic pathways at the cellular level. This contrasts with the situation in cancer biology for example, where detailed understanding of cell biology, including the immune response, is transforming treatment. To make such advances for patients with renal disease, our objective has been to develop a variety of clinical models and tools, and then establish new approaches to interrogate tissue cellular pathology. We apply gene editing, single cell transcriptomics, and renal and immune phenotyping, to models and human samples.
In particular our work focuses on glomerular protein leak, a hallmark of many renal pathologies.
Examples of our work
The effects of Immune complex deposition on glomerular renal cells in lupus nephritis
Autoimmune renal disease such as occurs in Systemic Lupus Erythematosus (SLE) is characterised by the deposition of immune complexes in the renal glomeruli, but little is understood about the cellular responses in the tissue that ultimately lead to renal failure for some patients with SLE. Using inducible models and spatial transcriptomics we are interrogating cellular signals and cross talk in the kidney.
The role of Prolidase in autoimmunity and T cell fate
Deficiency in the metalloproteinase prolidase results in a very rare condition with recurrent infections and in some cases autoimmune features including renal immune complex disease. In vivo knock out of the PEPD gene has identified key functions for prolidase in autoimmunity, renal disease and T cell differentiation.
Collaborators
Richard Cornall, University of Oxford
John Todd / Diabetes and Inflammation Laboratory, University of Oxford
Moin Saleem, University of Bristol
Rutger Ploeg / Oxford Transplant Biobank, University of Oxford
geneTIGA consortium https://www.genetiga-horizon.eu/
Recent publications
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B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting
Journal article
Deobagkar-Lele M. et al, (2024), Science Immunology, 9
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Multiscale topology classifies cells in subcellular spatial transcriptomics.
Journal article
Benjamin K. et al, (2024), Nature
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Demultiplexing of single-cell RNA-sequencing data using interindividual variation in gene expression
Journal article
Nassiri I. et al, (2024), Bioinformatics Advances, 4
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Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases
Journal article
Pagnamenta AT. et al, (2023), Genome Medicine, 15
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Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity
Journal article
Hodgson R. et al, (2023), The Journal of Immunology, 210, 547 - 557