Contact information
Ruksana Syeda
prof.ho.pa@imm.ox.ac.uk
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headington OX3 9DS
Interview: Immune responses in lung disease - Sarcoidosis
Ling-Pei Ho
DPhil, FRCP, MD
Professor of Respiratory Immunology
We are interested in how immunological responses impact on mechanisms of lung injury and repair. The projects are divided into mechanistic and translational studies. The mechanistic studies question how innate immune cells like iNKT cells, MDSCs and monocyte-macrophage lineage impact on outcome in severe influenza virus infection and progression of lung fibrosis. These studies inform, drive and allow us to test mechanistic hypotheses in/from our human work.
In the translational space, our focus is on new or improved therapy for lung fibrosis. Our diseases of interest are idiopathic pulmonary fibrosis (IPF) and fibrotic sarcoidosis, and we target the interface between cellular immunology, disease mechanisms and early clinical trials.
Current projects in the group
- Role of epithelial CD1d in local lung immune homeostasis and responses
- Impact of monocyte subtypes, monocyte-derived macrophages and MDSCs on immune response to pathogens
- Development of human lung organoid models for idiopathic pulmonary fibrosis
- Contribution of monocyte-macrophage subtypes to acceleration and acute exacerbations of idiopathic pulmonary fibrosis
- Examination of M-CSF/CSF-1R pathway as a potential therapy for IPF
Note: for Clinical Respiratory Specialist inquiries, Prof Ho's address is
Interstitial Lung Disease Service
Oxford Center for Respiratory Medicine
Churchill Hospital, Oxford OX3 7LJ
Recent publications
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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Journal article
Liew F. et al, (2024), Nature Immunology, 25, 607 - 621
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Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID‐19
Journal article
Devine K. et al, (2024), Clinical Endocrinology, 100, 317 - 327
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Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Journal article
Elneima O. et al, (2024), International Journal of Epidemiology, 53
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Immune mechanisms of granuloma formation in sarcoidosis and tuberculosis
Journal article
Weeratunga P. et al, (2024), Journal of Clinical Investigation, 134
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Long COVID research: an update from the PHOSP-COVID Scientific Summit
Journal article
Brightling CE. et al, (2023), The Lancet Respiratory Medicine, 11, e93 - e94
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Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
Journal article
Raman B. et al, (2023), The Lancet Respiratory Medicine, 11, 1003 - 1019
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Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.
Journal article
Weeratunga P. et al, (2023), Nature communications, 14